Publications & Projects

Representative Publications

1. Yingying Xu, Runjie Cai, Xiaokai Fan, Maoxuan Liu, Xiaochun Wan, Xiaolu Yang, Jiacheng Bi and Liang Chen*. TRIM11 potentiates antitumor immunity via inhibition of the IFN-gamma/PD-L1 axis. Cell Death & Differentiation, 2025. DOI: 10.1038/s41418-025-01610-8.

   2025Cell Death & Differentiation
2. Wanyi He, Congli Chen, Jiwei Zheng, Yanyan Li, Huaihuai Shi, Yimin Zhou, Meiqing Li, Ping Gong, Ke Liu, Ximing Shao, Xiaojun Yao, Hongchang Li*, Liang Chen*, Lijing Fang*. Targeted degradation of cell surface proteins through endocytosis triggered by cell-penetrating peptide-small molecule conjugates. Nature Communications, 2025, 16(1): 7575.

   2025Nature Communications
3. Wanyi He, Congli Chen, Runjie Cai, Jiwei Zheng, Mengyu Yao, Joong Sup Shim, Hang Fai Kwok, Xiaojun Yao, Lijing Fang*, Liang Chen*. Bifunctional compounds for targeted degradation of carbonic anhydrase IX through integrin-facilitated lysosome degradation. Journal of Biological Chemistry, 2025, 301.

   2025Journal of Biological Chemistry
4. Jiwei Zheng, Wanyi He, Jing Li, Xuejia Feng, Yanyan Li, Binghua Cheng, Yimin Zhou, Meiqing Li, Ke Liu, Ximing Shao, Jianchao Zhang, Hongchang Li*, Liang Chen*, Lijing Fang*. Bifunctional Compounds as Molecular Degraders for Integrin-Facilitated Targeted Protein Degradation. Journal of the American Chemical Society, 2022, 144: 21831-21836.

   2022JACS
5. Yanfeng Liu, Shishi Tao, Lijuan Liao, Yang Li, Hongchang Li, Zhihuan Li, Lilong Lin, Xiaochun Wan, Xiaolu Yang*, Liang Chen*. TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway. Nature Communications, 2020, 11(1): 348.

   2020Nature Communications
6. Jianchao Zhang, Xiaokai Fan, Lijuan Liao, Yan Zhu, Xiaochun Wan, Hai Rao and Liang Chen*. TRIM28 attenuates Bortezomib sensitivity of hepatocellular carcinoma cells through enhanced proteasome expression. Clinical and Translational Medicine, 2022, 12: e603.

   2022Clinical and Translational Medicine
7. Jianchao Zhang, Xiaokai Fan, Yunfan Zhou, Liang Chen* and Hai Rao*. The PRMT5-LSD1 axis confers Slug dual transcriptional activities and promotes breast cancer progression. Journal of Experimental & Clinical Cancer Research, 2022, 41: 191.

   2022JECCR
8. Yanfeng Liu, Yingying Xu, Fang Wang, Yu Tong, Hongchang Li, Xiaochun Wan, Xiaolu Yang, Liang Chen*. Inhibition of AMPK activity by TRIM11 facilitates cell survival of hepatocellular carcinoma under metabolic stress. Clinical and Translational Medicine, 2021, 11(12): e617.

   2021Clinical and Translational Medicine
9. Liang Chen, Guixin Zhu, Eleanor M. Johns, Xiaolu Yang*. TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14. Nature Communications, 2018, 9(1): 1223.

   2018Nature Communications
10. Liang Chen, Michael D. Brewer, Lili Guo, Ruoxing Wang, Peng Jiang, Xiaolu Yang*. Enhanced Degradation of Misfolded Proteins Promotes Tumorigenesis. Cell Reports, 2017, 18(13): 3143-3154.

    2017Cell Reports

Funded Research Projects