Member

Dr. Liang Chen
PI
Photo

Dr. Liang Chen

Dr. Chen is an Associate Professor and PhD Supervisor at Sun Yat-sen University School of Medicine. He received his PhD from the School of Life Sciences, Peking University in 2014. From 2014 to 2018, he conducted postdoctoral research at the Perelman School of Medicine, University of Pennsylvania, focusing on the regulation of protein homeostasis in cancer. From 2018 to 2025, he served as an independent principal investigator at the Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, where he established a cancer cell biology research group and continued related studies.

Current positionAssociate Professor and PhD Supervisor, Sun Yat-sen University School of Medicine
Talent programShenzhen Overseas High-Caliber Talent, 2018
Research fieldsCancer cell biology, protein homeostasis, targeted protein degradation and tumor immune regulation
Previous appointmentIndependent PI, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 2018-2025

Selected Achievements

  • Published 20 papers as corresponding author or first author in journals including Cell Death & Differentiation, Nature Communications, Journal of the American Chemical Society, Cell Reports, Journal of Experimental & Clinical Cancer Research and Clinical and Translational Medicine.
  • Led or participated in more than 10 research projects supported by the National Natural Science Foundation of China, the Ministry of Science and Technology, Guangdong Province and Shenzhen Municipality.
  • Filed 7 Chinese invention patent applications and obtained 1 authorized PCT patent.

Training and Service

  • Supervised or co-supervised more than 10 master’s and PhD students.
  • Three trainees have received national, provincial or municipal scholarship support.
  • Serves as a reviewer for journals including Signal Transduction and Targeted Therapy, Cell Reports, Molecular Cancer Therapeutics and Cell Death & Disease.

Lab Members

Research assistant portrait

Sijia Wang

Research Assistant

wangsijia202203@163.com

Born in Zhengzhou, Henan Province, I hold a Master's degree in Basic Medicine from Yan'an University. I currently work as a research assistant in Chen Lab, with my primary research focus on targeted protein degradation technologies.

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Runjie Cai

PhD Student

crj13428334242@163.com

Received a Bachelor's degree from Southern Medical University and a Master's degree from Southern University of Science and Technology. Currently pursuing a Ph.D. in Cell Biology at the Zhongshan School of Medicine, Sun Yat-sen University, with research focusing on targeted protein degradation and tumor immunotherapy.

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Xueling Diao

Master student

diaoxueling23@mails.ucas.ac.cn

I received my Master’s degree in Biological and Pharmaceutical Engineering from the University of Chinese Academy of Sciences, and I am currently working in the group, focusing on the Targeted Protein Degradation.

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Xi Xu

PhD Student

2311009@tongji.edu.cn

I am from Anqing City, Anhui Province. I obtained my Bachelor's degree in Traditional Chinese Medicine from Shanghai University of Traditional Chinese Medicine, and I am currently a direct-entry PhD student (enrolled in 2023) in Basic Medicine at Tongji University. It is my great honor to join the laboratory of Chen Lib. At present, I am dedicated to exploring the molecular mechanisms of key cell membrane receptors in the field of tumor immunology.

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Quanjiang Li

PhD Student

liqj25@mails.jlu.edu.cn

I am from Jilin City, Jilin Province, China. I received Master's degree in Biomedical Engineering from Guangdong University of Technology, and I am currently a 2025 Ph.D. student in Biochemistry and Molecular Biology at Jilin University. It is my great honor to join the Chen Lab. My current research is dedicated to exploring exosome-based immunocombination therapeutic strategies and their antitumor effects.

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Chengle Zhu

PhD Student

zchenglekiki@163.com

Zhu Chengle, a native of Mengcheng, Anhui, obtained his bachelor's and master's degrees from Bengbu Medical University. He is currently a Ph.D. candidate, focusing on microenvironment immune remodeling. He has published three papers as first author or co‑first author in internationally recognized SCI journals, including Cell Death & Disease.

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Fujiong Chen

Master student

fj.chen@siat.ac.cn

Second-year Joint-training Master Student, Shenzhen Institute of Advanced Technology, CAS.
Research Interests: Pulmonary fibrosis, targeted protein degradation (TPD). Additional research experience covers exosomes and tumor immunology.

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Zhixiang Hu

Master student

huzhx26@mail2.sysu.edu.cn

I am from Nanchang, Jiangxi Province, and hold a Bachelor’s degree in Biotechnology from Guangzhou Medical University. My current research is focused on unraveling the signaling pathway mechanisms of E3 ubiquitin ligases in cellular regulation.

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Jing Jin

Master student

jing.jin@siat.ac.cn

I am from Jinhua, Zhejiang Province.Currently a first-year joint-training Master student at Southern University of Science and Technology & Shenzhen University of Advanced Technology . My research focuses on targeted protein degradation (TPD) and bioactive glass applications.

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Xinyi Wo

Master student

woxinyi384@gmail.com

I previously worked in the Algal Resource Development Laboratory on the development of fucoxanthin from microalgae. Currently, I am involved in tumor immunology-related research at the Laboratory of Inflammatory Systems Medicine, focusing on the design of targeted drugs that respond to the tumor microenvironment.